Road safety minister Stephen Hammond has announced a set of new laws in effort to reduce "the menace of drug-driving".
People driving under the influence of heroin, cannabis, LSD and ecstasy will now face six months in jail and up to a £5,000 fine if they are found to have any amount in their system.
After announcing the measures, Mr Hammond said: "Drug-driving is a menace that claims an estimated 200 lives every years.
"That is why we are proposing to take a zero-tolerance approach with those that drive under the influence of illegal drugs and sending a clear message that this behaviour will not be tolerated.
"These proposals will make our roads safer for everyone by making it easier for the police to tackle those who drive under the influence [of drugs] and clarifying the position for those that take prescribed medications."
Road side tests will be carried out from next year to see if limits have been exceeded.
Eight prescription drugs, including diazapam and temazepam, will also feature on the 'zero-tolerance' list though limits for their use will be much higher.
The move was welcomed by road safety charity Brake, whose deputy chief executive Julie Townsend said: "We have campaigned for many years for tighter legislation on deadly drug-drivers to ensure they are caught and prosecuted before they cause destruction to lives.
"Brake therefore welcomes progress being made by the government and hope to see this continue apace with the approval of roadside screeners in the near future."
Draft regulations will cover England and Wales, with a consultation on policy options also covering Scotland due to run until 17 September.